Editorial: Can dysregulated myelination be linked to ADHD pathogenesis and persistence?
Klaus-Peter Lesch
Abstract
Converging evidence from new epidemiologic, genetic, epigenetic, neuroimaging, and experimental model findings are further refining a long‐standing concept, regarding the underlying neurobiology of attention‐deficit/hyperactivity disorder (ADHD): that ADHD onset and its persistence into adulthood are the result of dysregulated myelination and associated alterations in neuronal plasticity – linked to disrupted brain maturation and the persistence of cognitive and emotional impairments across the life span. If supported by further work, this concept represents a pathophysiologic mechanism amenable to therapeutic intervention.
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Klaus-Peter is a clinical psychiatrist who has been investigating the neurobiological foundation of personality traits. His 1996 paper on the association between the 5-HTTLPR polymorphism in the serotonin transporter gene and the personality trait neuroticism has been highly cited and was one of the first papers in personality genetics. He is a Professor at the University of Würzburg.
