Stratifying early-onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry

Featured ACAMH Papers

Bringing you some selected Open Access journal papers from our portfolio; The Journal of Child Psychology and Psychiatry (JCPP), Child and Adolescent Mental Health journal (CAMH), and JCPP Advances.

Posted on 19 July 2023

Tags: Attention-deficit/hyperactivity disorders (ADHD), Autism spectrum disorder (ASD)… Show all

Topics: Attention-deficit/hyperactivity disorders (ADHD), Autism spectrum disorder (ASD), Depression, Emotion, Genetics
Publication Types: Journal article, Risk prediction
Symptoms: emotional disturbance
Geography: United Kingdom

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‘Stratifying early-onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry’

Open Access paper from the JCPP

Depression and anxiety are the most common mental health problems in young people. Currently, clinicians are advised to wait before initiating treatment for young people with these disorders as many spontaneously remit. However, others develop recurrent disorder but this subgroup cannot be identified at the outset. We examined whether psychiatric polygenic scores (PGS) could help inform stratification efforts to predict those at higher risk of recurrence.

Authors: Charlotte A. Dennison, Joanna Martin, Amy Shakeshaft, Lucy Riglin, Frances Rice, Cathryn M. Lewis, Michael C. O’Donovan, Anita Thapar