Are some children genetically predisposed to poor sleep? A polygenic risk study in the general population

‘Are some children genetically predisposed to poor sleep? A polygenic risk study in the general population’

Open Access paper from the JCPP

Twin studies show moderate heritability of sleep traits: 40% for insomnia symptoms and 46% for sleep duration. Genome-wide association studies (GWAS) have identified genetic variants involved in insomnia and sleep duration in adults, but it is unknown whether these variants affect sleep during early development. We assessed whether polygenic risk scores for insomnia (PRS-I) and sleep duration (PRS-SD) affect sleep throughout early childhood to adolescence.

Authors: Desana Kocevska, Katerina Trajanoska, Rosa H. Mulder, M. Elisabeth Koopman-Verhoeff, Annemarie I. Luik, Henning Tiemeier, Eus J.W. van Someren

First published: 08 November 2023

https://doi.org/10.1111/jcpp.13899

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