Epigenetics
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DNA Methylation, Lateral Ventricular Volume, and Psychiatric Risk for Schizophrenia
In this Papers Podcast, Dr. Charlotte Cecil and Dr. Mannan Luo discusses their co-authored JCPP paper ‘DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study’.
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DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study
Open Access paper from the JCPP – ‘In this study, we conducted the first epigenome-wide association study of neonatal DNAm in cord blood with LVV in childhood (measured using T1-weighted brain scans at 10 years), based on data from a large population-based birth cohort, the Generation R Study (N = 840)’. Mannan Luo et al.
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Negative parenting, epigenetic age, and psychological problems: prospective associations from adolescence to young adulthood
Open Access paper from the JCPP – ‘This pre-registered longitudinal study examined the long-term effects of negative parenting and psychological problems throughout adolescence (ages 13–17 years) on Epigenetic Age acceleration (EA) in late adolescence (age 17 years) and EA changes from late adolescence to young adulthood (age 25 years).’ Stefanos Mastrotheodoros et al.
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Genome-wide DNA methylation analysis of aggressive behaviour: a longitudinal population-based study
Open Access paper from the JCPP – ‘We examined the association between aggressive behaviour, as measured by Life History of Aggression (LHA) total score and DNAm levels both assessed at age 25.’ Ehsan Pishva (pic) et al.
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Research Review: Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities
Open Access paper from JCPP Advances – “Epigenetic processes are fast emerging as a promising molecular system in the search for both biomarkers and mechanisms underlying human health and disease risk, including psychopathology”. Charlotte A. M. Cecil (pic) et al.
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JCPP Editorial: Volume 63, Issue 11, November 2022
Editorial: Accelerated epigenetic ageing as a consequence of early environmental adversity by Barbara Franke
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Genetics research informing mental health care
Anita Thapar discusses that genetic studies of mental health have revealed important insights about the influence of genes and the environment, and the nature of disorders. She explains how these insights could improve mental health care for young people and their families now and in the future.
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A mother’s touch: a key player in fine tuning the function of our genome
There is debate as to the importance of genetics in determining our behaviour. This debate has become enshrined perhaps due to the early focus of genetics on searching for DNA variation in our genome (termed a polymorphism) that affected protein structure, the hypothesis being that such a protein variant would not be working optimally in our body throughout our life.
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JCPP Editorial: Volume 60, Issue 03, March 2019
“Can dysregulated myelination be linked to ADHD pathogenesis and persistence?” by Klaus-Peter Lesch
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JCPP Annual Research Review
Free access to the articles included in the JCPP Annual Research Review, “Reimagining the environment in developmental psychopathology: from molecules to effective treatments”, until June 2018.
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